Catalog #: ACB01

Product Name: Acarbose

CAS Registry Number: 56180-94-0

Acarbose is an alpha-glucosidase inhibitor that reduces sugar absorption in the gastrointestinal tract, clinically used as an anti-diabetic agent. It's produced by fermentation of Actinoplanes sp.

Physico-Chemical Properties:

White or off-white amorphous powder; [a]D18 +165 (c = 0.4 in water); Soluble in water, insoluble in organic solvents.

References:

Isolation, Purification and Structure Determination:

W. Frommer et al., DE 2347782(1975 to Bayer);
W. Frommer et al., US 4062950 (1977 to Bayer).

Total Synthesis & Biosynthesis:

U. Degwert et al., J. Antibiot. 40, 855 (1987);
S. Ogawa et al., Chem. Commun. 1988, 605;
S. Ogawa et al., Carbohyd. Res. 189, 309 (1989).

HPLC Analysis:

M. Boberg et al., Arzneimittelforschung. 1990 May;40(5):555-63;
M. Konno et al., Rinsho Byori. 2004 Dec; 52(12):955-60.