Catalog #: ASC01

Product Name: Ascomycin

Other Names: FK-520

CAS Registry Number: 104987-12-4

Ascomycin is a macrolide immunosuppressant produced by fermentation of Streptomyces tsukubaensis or Streptomyces hygroscopicus var. ascomyceticus.

Physico-Chemical Properties:
White or off-white crystalline powder, mp: 159 °C - 164 ºC; soluble in methanol, ethanol, acetone, ethyl acetate, chloroform; insoluble in water.

References:

Isolation, Purification and Structure Determination:

M. Okuhara et al., EP 184162 (1986 to Fujisawa);
T. Kino et al., J. Antibiot. 40, 1249 (1987);
H. Tanaka et al., J. Am. Chem. Soc. 109, 5031 (1987).

Synthesis:

T. K. Jones et al., J. Am. Chem. Soc. 111, 1157 (1989).
T. K. Jones et al., EP 378318 (1990 to Merck & Co.).

HPLC analysis:

T. Akashi et al., J. Pharm. Biomed. Anal. 14(3):339-46 (1996);
T. Nishikawa et al., Pharm. Res. 10(12):1785-9T (1993).