Catalog #: MZR01

Product Name: Mizoribine

CAS Name: 5-Hydroxy-1-b-D-ribofuranosyl-1H-imidazole-4-carboxamide

CAS Registry Number: 50924-49-7

Mizoribine is a nucleoside produced by Eupenicillium brefedianum with antibiotic, cytotoxic and immunosuppressive activity.

Physico-Chemical Properties:

White or off white crystalline powder; mp > 200 DC (dec); [a]D27 -35 (c = 0.8 in water); pKa 6.75; uv max (water): 245, 279 nm (E 250, 580); Soluble in water; Slightly soluble in methanol, ethanol. Insoluble in most organic solvents.

References:

Isolation, Purification and Structure Determination:

K. Mizuno et al., US 3888843 (1975 to Toyo Jozo);
K. Mizuno et al., J. Antibiot. 27, 775 (1974).

Synthesis:

M. Hayashi et al., Chem. Pharm. Bull. 23, 245 (1975);
K. Fukukuwa et al., Chem. Pharm. Bull. 32, 1644 (1984).

HPLC analysis:

K. Takada et al., J. Chromatog. 222, 156 (1981).