Catalog #: PMC01

Product Name: Pimecrolimus

Other Name: 33-epi-Chloro-33-desoxyascomycin

CAS Registry Number: 137071-32-0

Pimecrolimus is a macrolide immunosuppressant produced by semisynthesis starting from ascomycin.

Physico-Chemical Properties:

Pimecrolimus is a white to off-white fine crystalline powder; UV max (95% ethanol) at 210 nm; It is soluble in methanol, ethanol, chloroform, acetone, and DMF; and insoluble in water.

References:

Synthesis:

K. Baumann et al., US Patent # 5912238 & 5352671 (both to Novartis).

HPLC analysis:

S. Baldelli, et al., J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2005 Feb 25; 816(1-2):99-105;

P. Salm, et al., J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2002 Jun 5; 772(2):283-90;

I. Segarra, et al., J. Chromatogr. B. Biomed. Sci. Appl. 1998 Dec 11; 720(1-2):179-87.