Catalog #: RPM01

Product Name: Rapamycin

Other Names: Sirolimus; RAPA; RPM; AY-22989; NSC-226080; Rapamune

CAS Registry Number: 53123-88-9

Rapamycin is a macrolide immunosuppressant isolated from Streptomyces hygroscopicus.

Physico-Chemical Properties:
Colorless crystalline solid, mp. 183--185 DC; UV max (95% ethanol): 267, 277, 288 nm (E1% 1cm: 417, 541, 416); Optical rotation ([a]D25): -58.2 (methanol); Soluble in ether, chloroform, acetone, methanol and DMF; very sparingly soluble in hexane and petroleum ether; insoluble in water.

References:

Isolation, Purification and Structure Determination:

S. Sehgal et al., DE 2347682; US 3929992 (1974, 1975 both to Ayerst);
C. Vézina et al., J. Antibiot. 28, 721 (1975);
S. Sehgal et al., J. Antibiot. 28, 727 (1975);
J. A. Findlay et al., Can. J. Chem. 58, 579 (1980);
T. G. Pagano et al., Magn. Reson. Chem. 43, 174-175 (2005).

Synthesis:

K. Nicolaou et al., J. Am. Chem. Soc. 115, 4419 (1993);
D. Romo et al., J. Am. Chem. Soc. 115, 7906 (1993).

HPLC analysis:

Di Marco, et al., Ther. Drug Monit. 25(5):558-564 (2003);
D. French, et al., Clin. Chem. 47(7):1316-1319 (2001);
J. Svensson, et al., Ther. Drug Monit. 19(1):112-116 (1997);
T. Nishikawa, et al., J. Antibiot. 47(12):1554-1556 (1994).