Catalog #: TCP01

Product Name: Teicoplanin

CAS Registry Number: 61036-64-4

Teicoplanin is a glycopeptide antibiotic complex produced by Actinoplanes teichomyceticus, structurally related to vancomycin, comprised of 5 major components differentiated by a specific fatty acid moiety. It inhibits peptidoglycan synthesis in the cell wall of gram-positive bacteria.

Physico-Chemical Properties:
White or off-white amorphous powder, mp 258--261 DC(dec.); UV max in 0.1 N HCl: 278 (E1% 1 cm: 53); in 0.1 N NaOH: 297 (E1% 1 cm, 74); Soluble in aqueous solution at pH 7.0; partially soluble in methanol, ethanol; Insoluble in dilute mineral acids, in non-polar organic solvents.

References:

Isolation, Purification and Structure Determination:

C. Coronelli et al., US 4239751 (1980 to Lepetit);
F. Parenti et al., J. Antibiot. 31, 276 (1978);
M. Bardone et al., J. Antibiot. 31, 170 (1978);
A. Borghi et al., US 4542018 (1985 to Lepetit);
A. Borghi et al., J. Antibiot. 37, 615 (1984);
C. Coronelli et al., J. Antibiot. 37, 621 (1984);
J. Barna et al., J. Am. Chem. Soc. 106, 4895 (1984).

Synthesis: N/A

HPLC analysis:

A. Georgopoulos et al., J. Chromatogr. 1989 Sep 29;494:340-6A